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Drugs and orgasm Psychotropic medications commonly produce anorgasmia as a side-effect. This includes the hippocampus, which is responsible for memory and fantasies, says Komisaruk. An increased infusion of the hormone oxytocin during ejaculation is believed to be chiefly responsible for the male refractory period, and the amount by which oxytocin is increased may affect the length of each refractory period. The main players are dopamine, the reward hormone; prolactin, the hormone of satiation; oxytocin, the cuddle hormone, and levels of androgen receptors, which all powerfully affect our mood, our desire for intimacy, our perception of our mate, as well as our susceptibility to addictive activities and substances. Textbook of biological psychiatry. This is when the hypothalamus and nucleus accumbens, which basically produce the grand finale of brain responses, are activated. Instead, research only shows that oxytocin is an effect of orgasms.
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